Paper-based assays for urine analysis

Three-dimensional paper-based microfluidic device for assays of protein and glucose in urine.

The first step in curing a disease is being able to detect the disease effectively. Paper-based microfluidic devices are biodegradable and can make diagnosing diseases cost-effective and easy in almost all environments. We created a three-dimesnional (3D) paper device using wax printing fabrication technique and basic principles of origami. This design allows for a versatile fabrication techniq...

Low-cost Paper-based Assays for Multiplexed Genetic Analysis Using Surface Enhanced Raman Spectroscopy

Title of dissertation: LOW-COST PAPER-BASED ASSAYS FOR MULTIPLEXED GENETIC ANALYSIS USING SURFACE ENHANCED RAMAN SPECTROSCOPY Eric Peter Hoppmann, Doctor of Philosophy, 2013 Dissertation directed by: Professor Ian White Department of Bioengineering In order to improve human health it is critical to develop low-cost sensors for chemical detection and healthcare applications. Low-cost chemical de...

A Paper-based Analytical Device for Electrochemical Flow Injection Analysis of Glucose in Urine

Paper-based analytical device for electrochemical flow-injection analysis of glucose in urine.

This article describes a new design for a paper-based electrochemical system for flow-injection analysis. Capillary wicking facilitates a gravity-driven flow of buffer solution continuously through paper and nitrocellulose, from a buffer reservoir at one end of the device to a sink at the other. A difference in height between the reservoir and the sink leads to a continuous and constant flow. T...

Antimicrobial susceptibility assays in paper-based portable culture devices.

To detect antibiotic-resistant bacteria in areas remote from microbiology laboratories, we designed portable culture devices performing an analogue of the Kirby-Bauer disk diffusion test inside patterned papers embedded in tape. We quantified the antibiotic susceptibility of several strains of Escherichia coli and Salmonella typhimurium by measuring blue-colored zones of inhibited growth.